Who should you start? Who should you sit? To help you set your fantasy football lineups and to avoid starting a player who won't be in the lineup, we'll post fantasy-relevant updates and analysis here as NFL teams release their official inactives lists, typically about 90 minutes before kickoff. Any rankings cited in this column come from our ESPN Fantasy staff ranks.
Lamar Jackson, QB, BAL: Back -- Active
Impact: Jackson will play, with new backfieldmate RB Le'Veon Bell possibly in the mix for carries. Ty'Son Williams is inactive.
Melvin Gordon III, RB, DEN: Ribs -- Active
Impact: Either way, Javonte Williams may well end up with the most touches in the Denver backfield.
Marquez Valdes-Scantling, WR, GB: Hamstring -- OUT/IR
Impact: Could Allen Lazard have one or two splash plays in him?
Darrell Henderson Jr., RB, LAR: Ribs -- Active
Impact: Buddy Howell again gets the call from the practice squad, but Henderson is still going to play.
Chase Claypool, WR, PIT: Hamstring -- OUT
Impact: TE Pat Freiermuth may end up as the biggest beneficiary of Claypool's absence in terms of targets.
Rashaad Penny, RB, SEA: Calf -- OUT/IR
Impact: Alex Collins and Travis Homer will back up Chris Carson.
Dee Eskridge, WR, SEA: Concussion -- Inactive
Impact: It's been a tough few weeks for Eskridge, which has led to more work for Freddie Swain.
Tyler Lockett, WR, SEA: Hip -- Active
Impact: He was always expected to give it a go on Sunday.
Gerald Everett, TE, SEA: COVID-19 -- Inactive
Impact: Will Dissly will get the start in his stead.
Elijah Mitchell, RB, SF: Shoulder -- Inactive
Impact: Take a shot and roll with either Trey Sermon or even Kyle Juszczyk.
George Kittle, TE, SF: Calf -- Active
Impact: With a talent like Kittle, it's hard not to start him when he's active, even if he might be dealing with some bumps and bruises.
Defense
Derek Wolfe, DE, BAL: Back -- OUT/IR
Tavon Young, CB, BAL: Knee -- Active
Marlon Humphrey, CB, BAL: Knee -- Active
Chuck Clark, S, BAL: Hip -- Active
Anthony Averett, CB, BAL: Ankle -- Active
DeShon Elliott, S, BAL: Quad -- Active
Shelby Harris, DE, DEN: Wrist -- Active
Dre'Mont Jones, DE, DEN: Calf -- Active
Krys Barnes, LB, GB: Concussion -- Inactive
Kevin King, CB, GB: Concussion -- Inactive
Benson Mayowa, DE, SEA: Neck -- Inactive
Javon Kinlaw, DT, SF: Knee -- Active
K'Waun Williams, CB, SF: Calf -- OUT
1 p.m. ET games
Offense
Russell Gage, WR, ATL: Ankle -- OUT
Impact: Olamide Zaccheaus should continue to see increased action in the slot.
Christian McCaffrey, RB, CAR: Hamstring -- OUT
Impact: Chuba Hubbard and Royce Freeman will attempt to fill his very large shoes.
Andy Dalton, QB, CHI: Knee -- Inactive
Impact: Justin Fields had already been announced as the Week 4 starter.
Darnell Mooney, WR, CHI: Groin -- Active
Impact: As he played through this same injury last week, we're not shocked to see him on the field today.
D'Andre Swift, RB, DET: Groin -- Active
Impact: He was limited in practice this week, but was never expected to miss this game.
Deshaun Watson, QB, HOU: Team decision -- OUT
Impact: Davis Mills continues to start, and struggle, for the Texans.
Danny Amendola, WR, HOU: Thigh -- OUT
Impact: Chris Conley and Anthony Miller to get a lot more snaps.
Carson Wentz, QB, IND: Ankle -- Active
Impact: Wentz is going to play through his injury woes. Jacob Eason is inactive.
Jonathan Taylor, RB, IND: Knee -- Active
Impact: The Colts are a very banged-up offense right now.
Jack Doyle, TE, IND: Back -- Active
Impact: Practiced a bit on Friday, so his start today is not a huge surprise.
Dalvin Cook, RB, MIN: Ankle -- Active
Impact: Practiced at least a little bit every day this week.
Sterling Shepard, WR, NYG: Hamstring -- OUT
Impact: Collin Johnson and Kadarius Toney to supplement Kenny Golladay.
Darius Slayton, WR, NYG: Hamstring -- OUT
Impact: John Ross was activated from IR but is unlikely to see much action, if any.
Kaden Smith, TE, NYG: Knee -- Active
Impact: We're still waiting for either Smith or Evan Engram to have a breakout game.
La'Mical Perine, RB, NYJ: Illness -- Inactive
Impact: Michael Carter, Tevin Coleman, and Ty Johnson are likely to battle for touches.
Elijah Moore, WR, NYJ: Concussion -- OUT
Impact: His absence will allow Denzel Mims to suit up this week.
Jamison Crowder, WR, NYJ: Groin -- Active
Impact: Practiced Friday and is feeling good enough to make his 2021 debut.
Tyler Kroft, TE, NYJ: Ribs -- Active
Impact: He is going to play, but Ryan Griffin is waiting in the wings.
Julio Jones, WR, TEN: Hamstring -- OUT
Impact: Nick Westbrook-Ikhine and Josh Reynolds will attempt to step up their games.
A.J. Brown, WR, TEN: Hamstring -- OUT
Impact: Marcus Johnson and Chester Rogers might also get a lot more looks.
Antonio Gibson, RB, WAS: Shin -- Active
Impact: He apparently got through the morning without any major setbacks.
Defense
Jordan Poyer, S, BUF: Ankle -- OUT
Taron Johnson, CB, BUF: Groin -- Inactive
Khalil Mack, LB, CHI: Foot -- Active
Tashaun Gipson Sr., S, CHI: Hamstring -- Inactive
Sione Takitaki, LB, CLE: Hamstring -- Active
Greg Newsome II, CB, CLE: Calf -- OUT
Carlos Watkins, DT, DAL: Knee -- OUT
Dorance Armstrong, DE, DAL: Ankle -- OUT
Donovan Wilson, S, DAL: Groin -- OUT
Trey Flowers, DE, DET: Shoulder -- OUT
Michael Brockers, DT, DET: Shoulder -- Active
Romeo Okwara, DE, DET: Shoulder -- Active
Garret Wallow, LB, HOU: Illness -- Active
Terrance Mitchell, CB, HOU: Concussion -- Active
Zach Cunningham, LB, HOU: COVID-19 -- Inactive
Kwity Paye, DE, IND: Hamstring -- OUT
Khari Willis, S, IND: Groin -- OUT
Frank Clark, DE, KC: Hamstring -- Inactive
Charvarius Ward, CB, KC: Quad -- Inactive
Michael Pierce, DT, MIN: Elbow -- Active
Anthony Barr, LB, MIN: Knee -- Inactive
Tae Crowder, LB, NYG: Hamstring -- Active
Marcus Maye, S, NYJ: Ankle -- OUT
Bud Dupree, LB, TEN: Knee -- OUT
